TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome.
TET inhibitor C35 is a general TET inhibitor that targets all members of the TET family.
TET inhibitor C35 also suppresses the catalytic activities of TET1 and TET3 with IC50 3.48 uM and 2.31 uM, respectively.
TET inhibitor C35 treatment reduces genome-wide 5hmC level in human and mouse cells.
TET inhibitor C35 promotes somatic cell reprogramming induces the expression of members of the BMP-SMAD-ID axis.
