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TG-0205221

Chemical Structure : TG-0205221

CAS No.: 856242-63-2

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TG-0205221 (TG0205221, MPI8)

Catalog No.: PC-72196Not For Human Use, Lab Use Only.

TG-0205221 (MPI8) is a potent SARS-CoV 3CL protease (3CLpro) inhibitor with Ki of 53/68 nM against SARS-CoV 3CLpro/ HCoV 229E 3CLpro, respectively.

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    Biological Activity

    TG-0205221 (MPI8) is a potent SARS-CoV 3CL protease (3CLpro) inhibitor with Ki of 53/68 nM against SARS-CoV 3CLpro/ HCoV 229E 3CLpro, respectively.
    TG-0205221 showed remarkable activity against SARS CoV (IC50=0.16 uM) and HCoV 229E (IC50=0.6 uM) replications by reducing the viral titer by 4.7 log (at 5 µM) for SARS CoV and 5.2 log (at 1.25 µM) for HCoV 229E.

    Physicochemical Properties

    M.Wt 600.757
    Formula C32H48N4O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    benzyl ((2S,3S)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

    References

    1. Syaulan Yang, et al. J Med Chem. 2006 Aug 10;49(16):4971-80.

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