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TG-6304

Chemical Structure : TG-6304

CAS No.:

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TG-6304 (TG6304)

Catalog No.: PC-72009Not For Human Use, Lab Use Only.

TG-6304 (TG6304) is a first-in-class, potent, highly selective, cell-permeable DCN3 inhibitor with Ki of 35 nM, does not bind to DCN1 at 30 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TG-6304 (TG6304) is a first-in-class, potent, highly selective, cell-permeable DCN3 inhibitor with Ki of 35 nM, does not bind to DCN1 at 30 uM.
    TC-6304 engages DCN3 in cells in a dose-dependent manner but does not affect the neddylation of any of the cullins.
    TC-6304 effectively enhances the thermal stability of cellular DCN3 protein in a dose-dependent manner and has no significant effect on the thermal stability of cellular DCN1 protein (10-1000 nM).

    Physicochemical Properties

    M.Wt 583.139
    Formula C31H33ClF2N4OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(5-(3-chlorophenyl)-4-methylthiazol-2-yl)-2-((3,5-difluorophenyl)amino)-N-((S)-1-(dimethylamino)-3-(p-tolyl)propan-2-yl)propanamide

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