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Chemical Structure : TG693
CAS No.: 885272-55-9
Catalog No.: PC-61023Not For Human Use, Lab Use Only.
TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $478 | In stock | |
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| 200 mg | Get quote |
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TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
TG693 also potently inhibits haspin activity and weakly inhibits DYRK kinases in a panel of 313 recombinant kinases.
TG693 promotes the skipping of the endogenous mutated exon 31 in DMD patient-derived cells and increases the production of the functional exon 31-skipped dystrophin protein.
TG693 inhibits the phosphorylation of CLK1 substrate serine/arginine-rich proteins and modulates pre-mRNA splicing in the skeletal muscle in mice.
| M.Wt | 195.225 | |
| Formula | C12H9N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(pyridin-4-yl)-1H-indazole |
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1. Sako Y, et al. Sci Rep. 2017 May 30;7:46126.
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