Catalog No.: PC-35851Not For Human Use, Lab Use Only.
TH-257 (TH257) is a potent, selective, allosteric inhibitor of LIMK1 and LIMK2 with IC50 of 84 nM for LIMK1 and 39 nM for LIMK2 in a RapidFire MS assay.
TH-257 (TH257) is a potent, selective, allosteric inhibitor of LIMK1 and LIMK2 with IC50 of 84 nM for LIMK1 and 39 nM for LIMK2 in a RapidFire MS assay.
TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 uM.
TH-257 displays IC50 of 250 nM against ectopically expressed full-length LIMK1 and 150 nM LIMK2 in a life cell NanoBRET assay.
Physicochemical Properties
M.Wt
422.543
Formula
C24H26N2O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide
References
1. Manetti F. et al. Eur J Med Chem. 2018 Jul 15;155:445-458.
2. Collins R, et, al. J Med Chem. 2022 Oct 27;65(20):13705-13713.
