Chemical Structure : TH-407b
CAS No.:
2616629-76-4
TH-407b
(TH407b)
Catalog No.: PC-23645Not For Human Use, Lab Use Only.
TH-407b is a potent and selective TLR7 inhibitor, dose-dependently inhibits R848-induced TLR7 activation with IC50 of 0.23 uM in HEK-Blue hTLR7 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TH-407b is a potent and selective TLR7 inhibitor, dose-dependently inhibits R848-induced TLR7 activation with IC50 of 0.23 uM in HEK-Blue hTLR7 cells.
TH-407b binds to TLR7 (ITC KD=5.1 uM) and induces receptors dimerization, stabilizes the inactivated dimeric state.
TH-407b inhibits TLR7 signaling pathway and TLR7-mediated cytokine production.
TH-407b not only effectively inhibits TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrates potent inflammation suppressing activities in primary peripheral blood mononuclear cells (PBMCs) derived from systemic lupus erythematosus (SLE) patients.
TH-407b shows prominent efficacy in vivo, improves survival rate and ameliorates symptoms of SLE model mice.
Physicochemical Properties
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M.Wt
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434.49
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Formula
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C24H26N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Tricyclo[3.3.1.13,7]decan-2-one, 5-[[4-(8-nitro-5-quinolinyl)-1-piperazinyl]carbonyl]-
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References
1. Wang M, et al. Acta Pharm Sin B. 2024 Nov;14(11):4899-4913.
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