TH470 | LIMK inhibitor | Probechem Biochemicals

Chemical Structure : TH470

CAS No.: 2834739-51-2

TH470 (TH-470)

Catalog No.: PC-49369Not For Human Use, Lab Use Only.

TH470 (TH-470) is a potent, highly selective type II LIMK1/2 inhibitor with cellular IC50 of 9.8 and 13 nM, respectively.

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Biological Activity

TH470 (TH-470) is a potent, highly selective type II LIMK1/2 inhibitor with cellular IC50 of 9.8 and 13 nM, respectively.
TH470 showed excellent selectivity in a comprehensive scanMAX kinase selectivity panel.

Physicochemical Properties

M.Wt	605.728
Formula	C30H31N5O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(N-benzyl-4-(N-phenylsulfamoyl)benzamido)ethyl)-2-isobutyramidothiazole-5-carboxamide

References

1. Hanke T, et al. J Med Chem. 2022 Oct 13;65(19):13264-13287.

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TH470 (TH-470)

Biological Activity

Physicochemical Properties

References

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