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THIQ

Chemical Structure : THIQ

CAS No.: 312637-48-2

THIQ (MC4R agonist THIQ)

Catalog No.: PC-70060Not For Human Use, Lab Use Only.

THIQ is a potent and selective melanocortin 4 receptor (MC4R) agonist with EC50 of 2.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

THIQ is a potent and selective melanocortin 4 receptor (MC4R) agonist with EC50 of 2.1 nM.
THIQ has high selectivity over other melanocortin receptors (1184-fold vs MC3R, 350-fold vs MC5R).
THIQ enhances intracavernosal pressure and stimulates erectile activity in rats ex copula.

Physicochemical Properties

M.Wt 589.181
Formula C33H41ClN6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-N-((R)-1-(4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

References

1. Sebhat IK, et al. J Med Chem. 2002 Oct 10;45(21):4589-93.

2. Martin WJ, et al. Eur J Pharmacol. 2002 Nov 1;454(1):71-9.

3. Molden BM, et al. Mol Endocrinol. 2015 Nov;29(11):1619-33.

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