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TIPP-204

Chemical Structure : TIPP-204

CAS No.: 943544-10-3

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TIPP-204 (TIPP204)

Catalog No.: PC-23874Not For Human Use, Lab Use Only.

TIPP-204 is a potent, selective PPARδ agonist with EC50 of 0.91 nM, >250-fold selective PPARα and PPARγ.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TIPP-204 is a potent, selective PPARδ agonist with EC50 of 0.91 nM, >250-fold selective PPARα and PPARγ.
TIPP-204 exhibits extremely potent PPARδ transactivation activity, comparable with or somewhat superior to that of the known PPARδ-selective agonist GW-501516.
TIPP-204 does not significantly activate VDR, PPARγ, LXRα, RARα or RXRα at concentrations up to 300 nM.
TIPP-204 regulated the expression of genes involved in lipid and glucose homeostasis.

Physicochemical Properties

M.Wt 469.48
Formula C24H27F4NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(4-butoxy-3-((2-fluoro-4-(trifluoromethyl)benzamido)methyl)benzyl)butanoic acid

References

1. Kasuga J, et al. Bioorg Med Chem. 2007 Aug 1;15(15):5177-90.

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