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Chemical Structure : TK106
CAS No.: 57265-65-3
Catalog No.: PC-49318Not For Human Use, Lab Use Only.
TK106 (Calmidazolium chloride) is a small molecule non-competitive inhibitor of hSARM1 with IC50 of 10.8 uM, induces and promotes the formation of SARM1 octamers, also binds to calmodulin with a Kd of 3 nM.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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TK106 (Calmidazolium chloride) is a small molecule non-competitive inhibitor of hSARM1 with IC50 of 10.8 uM, induces and promotes the formation of SARM1 octamers, also binds to calmodulin with a Kd of 3 nM.
TK106 (Calmidazolium chloride) also is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively.
| M.Wt | 687.688 | |
| Formula | C31H23Cl7N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(bis(4-chlorophenyl)methyl)-3-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-3-ium chloride |
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1. Tami Khazma, et al. A Duplex Structure of SARM1 Octamers Induced by a New Inhibitor.
2. Budu A, et al. Cell Signal. 2016 Mar;28(3):125-135.
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