TKK130 | Antimalarial | Probechem Biochemicals

Chemical Structure : TKK130

TKK130 (TKK-130)

Catalog No.: PC-23704Not For Human Use, Lab Use Only.

TKK130 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), inhibits synthetic hemozoin (β-hematin) formation, shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=2-12 nM).

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Biological Activity

Physicochemical Properties

M.Wt	498.85
Formula	C24H17ClF6N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(1,3-difluoro-6-(trifluoromethyl)phenanthren-9-yl)-N'-(4-fluorophenyl)-3-hydroxypropanimidamide hydrochloride

References

1. Knaab TC, et al. J Med Chem. 2024 Dec 26. doi: 10.1021/acs.jmedchem.4c01465.

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TKK130 (TKK-130)

Biological Activity

Physicochemical Properties

References

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