Chemical Structure : TL1228
CAS No.:
2320491-70-9
TL1228
(TL-1228)
Catalog No.: PC-23213Not For Human Use, Lab Use Only.
TL1228 is a small molecule inhibitor of SARS-CoV-2 and its target cells, blocking the recognition of the GRP78 cellular receptor by the viral Spike protein, also is a selective inhibitor of the dihydrofolate reductase (DHFR) type B1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TL1228 is a small molecule inhibitor of SARS-CoV-2 and its target cells, blocking the recognition of the GRP78 cellular receptor by the viral Spike protein, also is a selective inhibitor of the dihydrofolate reductase (DHFR) type B1.
TL1228 (30 and 40 µM) hampers the VSV_Pseudo SARS-CoV-2 S Omicron BA.4/5 and BQ1.1 variants in Vero E6 cells.
TL1228 hinders the infection by VSV_Pseudo SARS-CoV-2 S Omicron BQ1.1 and XBB.1.5 in Calu-3 cells.
TL1228 affects VSV_Pseudo SARS-CoV-2 S Omicron XBB.1.5 infection.
Physicochemical Properties
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M.Wt
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564.55
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Formula
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C31H24N4O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,2'-(((2-hydroxypropane-1,3-diyl)bis(oxy))bis(3,1-phenylene))bis(1H-benzo[d]imidazole-5-carboxylic acid)
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References
1. Bastien D, J Med Chem. 2012;55:3182–92.
2. Michela Murdocca, et al. Biol Direct. 2024 Oct 16;19(1):93.
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