Catalog No.: PC-38651Not For Human Use, Lab Use Only.
TLK1 inhibitor J54 (J3-54) is a potent, small-molecule TLK1 inhibitor, induces apoptosis in AS PCa cells, suppresses growth of LNCaP xenografts combined with bicalutamide.
TLK1 inhibitor J54 (J3-54) is a potent, small-molecule TLK1 inhibitor, induces apoptosis in AS PCa cells, suppresses growth of LNCaP xenografts combined with bicalutamide.
J54 showed much weaker binding to the DR2 than THD or risperidone.
J54 exhibits TLK1 inhibition with reduced pAKT S473 levels in a dose-dependent manner.
Physicochemical Properties
M.Wt
312.431
Formula
C18H20N2OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-(2-(10H-phenothiazin-10-yl)ethyl)morpholine
References
1. Vibha Singh, et al. iScience. 2020 Aug 20;23(9):101474.
