Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TLR7-TLR8 agonist 31
Catalog No.: PC-35315Not For Human Use, Lab Use Only.
TLR7 and 8 modulator 31 is a potent, orally active, dual TLR7 and 8 agonist with LEC values of 0.15 and 0.16 uM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TLR7/TLR8 modulator 31 is a potent, orally active, dual TLR7 and 8 agonist with LEC values of 0.15 and 0.16 uM, respectively.
TLR7/TLR8 modulator 31 displays a good off-target profile (Aa1A, D1, 5HT2A IC50>10 µM; CYP 2D6 IC50=5.7 µM), also shows no significant activity against a panel of 80 receptors.
TLR7/TLR8 modulator 31 induces IFNα and pro-inflammatory cytokines at low dose in vivo, inhibits HBV replication indirectly, via cytokine induction and immune cells activation.
TLR7/TLR8 modulator 31 induces endogenous IFNα, an interferon stimulated gene response (ISGs), and also activation of myeloid dendritic cells and monocytes towards a TH1 phenotype in both mice and cynomolgus monkeys in vivo.
| M.Wt | 278.331 | |
| Formula | C14H19FN4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Embrechts W, et al. J Med Chem. 2018 Jul 2. doi: 10.1021/acs.jmedchem.8b00643.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
