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TLX agonist 3

Chemical Structure : TLX agonist 3

CAS No.: 3032232-47-3

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TLX agonist 3 (Compound 10)

Catalog No.: PC-72812Not For Human Use, Lab Use Only.

TLX agonist 3 (Compound 10) is potent, selective agonist of the orphan nuclear receptor tailless homologue (TLX, NR2E1) with pEC50 of 6.6.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TLX agonist 3 (Compound 10) is potent, selective agonist of the orphan nuclear receptor tailless homologue (TLX, NR2E1) with pEC50 of 6.6.
    TLX agonist 3 is a valuable TLX agonist tool with submicromolar potency and high selectivity over related nuclear receptors, rendering it suitable for functional studies on TLX.

    Physicochemical Properties

    M.Wt 468.480
    Formula C25H23F3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-butoxy-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

    References

    1. Giuseppe Faudone, et al. J Med Chem. 2022 Jan 6. doi: 10.1021/acs.jmedchem.1c01757.

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