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TMP-153

Chemical Structure : TMP-153

CAS No.: 128831-46-9

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TMP-153 (TMP153)

Catalog No.: PC-63363Not For Human Use, Lab Use Only.

TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.
    TMP-153 inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively).
    TMP-153 inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.

    Physicochemical Properties

    M.Wt 437.9
    Formula C24H18ClF2N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N'-(2,4-difluorophenyl)-urea

    References

    1. Sugiyama Y, et al. Atherosclerosis. 1995 Feb;113(1):71-8.

    2. Sugiyama Y, et al. Atherosclerosis. 1995 Nov;118(1):145-53.

    3. Tawada H, et al. J Med Chem. 1994 Jun 24;37(13):2079-84.

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