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Chemical Structure : TMP-153
Catalog No.: PC-63363Not For Human Use, Lab Use Only.
TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.
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TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.
TMP-153 inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively).
TMP-153 inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.
| M.Wt | 437.9 | |
| Formula | C24H18ClF2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sugiyama Y, et al. Atherosclerosis. 1995 Feb;113(1):71-8.
2. Sugiyama Y, et al. Atherosclerosis. 1995 Nov;118(1):145-53.
3. Tawada H, et al. J Med Chem. 1994 Jun 24;37(13):2079-84.
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