Catalog No.: PC-60454Not For Human Use, Lab Use Only.
TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity.
TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity.
TMP778 blocks human Th17 and Tc17 cell differentiation and also acutely modulates IL-17A production and inflammatory Th17-signature gene expression (IL17a, IL17f, IL22, IL26, CCR6, and IL23) in mature human Th17 effector/memory T cells.
TMP778 inhibits IL-17A production in both human and mouse γδ T cells, also inhibits IL-23-induced IL-17A production.
TMP778 attenuates IMQ-induced skin inflammation in vivo.
