Catalog No.: PC-23483Not For Human Use, Lab Use Only.
TMPRSS2 inhibitor BC-11 hydrobromide is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay.
TMPRSS2 inhibitor BC-11 hydrobromide is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay. BC-11 is inactive against three proteases (furin, CATSB, and CATSL). BC-11 showed modest inhibition of SARS-CoV-2 entry with EC50 of 66 uM. A combination of the direct- and indirect-acting antivirals (BC-11 and AHN 1-055) demonstrated better viral entry inhibition than either compound alone.
