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Chemical Structure : TMPyP4 tosylate
CAS No.: 36951-72-1
Catalog No.: PC-62154Not For Human Use, Lab Use Only.
TMPyP4 tosylate (TMP1363) is a potent inhibitor of human telomerase with IC50 of 6.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 200 mg | $198 | In stock | |
| 1 g | Get quote |
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TMPyP4 tosylate (TMP1363) is a potent inhibitor of human telomerase with IC50 of 6.5 uM.
TMPyP4 tosylate (TMP1363) binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition.
TMPyP4 tosylate (TMP1363) treatment causes reduction in telomere length, and decline of myeloma cell growth.
| M.Wt | 1363.6 | |
| Formula | C72H66N8O12S4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in H2O (13.6 mg/mL) |
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| Chemical Name/SMILES |
5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate) |
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1. Phan AT, et al. Nat Chem Biol. 2005 Aug;1(3):167-73.
2. Shi DF, et al. J Med Chem. 2001 Dec 20;44(26):4509-23.
3. Shammas MA, et al. Mol Cancer Ther. 2003 Sep;2(9):825-33.
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