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TMPyP4 tosylate

Chemical Structure : TMPyP4 tosylate

CAS No.: 36951-72-1

TMPyP4 tosylate (TMP1363, TMP 1363)

Catalog No.: PC-62154Not For Human Use, Lab Use Only.

TMPyP4 tosylate (TMP1363) is a potent inhibitor of human telomerase with IC50 of 6.5 uM.

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Biological Activity

TMPyP4 tosylate (TMP1363) is a potent inhibitor of human telomerase with IC50 of 6.5 uM.
TMPyP4 tosylate (TMP1363) binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition.
TMPyP4 tosylate (TMP1363) treatment causes reduction in telomere length, and decline of myeloma cell growth.

Physicochemical Properties

M.Wt 1363.6
Formula C72H66N8O12S4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in H2O (13.6 mg/mL)

Chemical Name/SMILES

5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)

References

1. Phan AT, et al. Nat Chem Biol. 2005 Aug;1(3):167-73.

2. Shi DF, et al. J Med Chem. 2001 Dec 20;44(26):4509-23.

3. Shammas MA, et al. Mol Cancer Ther. 2003 Sep;2(9):825-33.

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