Chemical Structure : TMU4142
CAS No.:
TMU4142
(TMU-4142)
Catalog No.: PC-25733Not For Human Use, Lab Use Only.
TMU4142 is a potent, GoA pathway-selective 5-HT1A receptor (5-HT1AR) agonist with pEC50 of 8.80 (EC50=1.59 nM), Emax=92.78%.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TMU4142 is a potent, GoA pathway-selective 5-HT1A receptor (5-HT1AR) agonist with pEC50 of 8.80 (EC50=1.59 nM), Emax=92.78%.
TMU4142 displays nearly full agonist activity at the 5-HT1AR GoA pathway, whereas its Gi3 activity is significantly lower than that of 5-HT.
TMU4142 strongly activates the GoA protein over other tested Gi/o family proteins.
TMU4142 shows no discernible activity at 5-HT1AR β-arrestin-2 pathway, and weak or no activity at other serotonin and dopamine receptors.
TMU4142 (1.5 mg/kg) elicits rapid antidepressant-like activity without triggering significant DRN autoreceptor activation in mouse model of depression.
Physicochemical Properties
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M.Wt
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413.52
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Formula
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C23H31N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-8-(3-((3-((1H-indol-4-yl)oxy)-2-hydroxypropyl)amino)propyl)-8-azaspiro[4.5]decane-7,9-dione
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References
1. Wang C, et al. Cell. 2025 Nov 12:S0092-8674(25)01194-8.
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