TN1 | HbF inducer | Probechem Biochemicals

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Chemical Structure : TN1

CAS No.: 289479-94-3

TN1 (TN-1, HbF inducer TN1)

Catalog No.: PC-42268Not For Human Use, Lab Use Only.

TN1 is a potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM.

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10 mg	$398	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TN1 is a potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM.
At 100 nM, increases γ-globin expression (2.9- and 3.7-fold increase in KU812 cell and K562 cell, respectively) to higher levels than 50–100 uM hydroxyurea.
TN1 is a useful starting point for the generation of compounds that can be used for the treatment of SCD.

Physicochemical Properties

M.Wt	509.6021
Formula	C29H31N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propynamide, N-[3-[[9-ethyl-2-[(trans-4-hydroxycyclohexyl)amino]-9H-purin-6-yl]amino]phenyl]-3-(4-methylphenyl)-

References

1. Nam TG, et al. ChemMedChem. 2011 May 2;6(5):777-80.

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TN1 (TN-1, HbF inducer TN1)

Biological Activity

Physicochemical Properties

References

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