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Chemical Structure : TOK-001
CAS No.: 851983-85-2
Catalog No.: PC-45936Not For Human Use, Lab Use Only.
TOK-001 (Galeterone) is a potent 17α-hydroxylase/17,20-lyase (CYP17) inhibitor with IC50 of 300 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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TOK-001 (Galeterone) is a potent 17α-hydroxylase/17,20-lyase (CYP17) inhibitor with IC50 of 300 nM.
TOK-001 (Galeterone) also shown to be potent pure AR antagonist.
TOK-001 (Galeterone) inhibits the growth of DHT-stimulated LNCaP and LAPC4 prostate cancer cells with IC50 <10 uM.
TOK-001 (Galeterone) causes marked down-regulation of AR protein expression, more efficacious than castration in the LAPC4 xenograft model.
| M.Wt | 388.5451 | |
| Formula | C26H32N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 18 mg/mL |
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| Chemical Name/SMILES |
Androsta-5,16-dien-3-ol, 17-(1H-benzimidazol-1-yl)-, (3.beta.)- |
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1. Handratta VD, et al. J Med Chem. 2005 Apr 21;48(8):2972-84.
2. Vasaitis T, et al. Mol Cancer Ther. 2008 Aug;7(8):2348-57.
3. Bruno RD, et al. Mol Cancer Ther. 2008 Sep;7(9):2828-36.
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