Chemical Structure : TOP5300
CAS No.:
1848981-48-5
TOP5300
(TOP 5300, TOP05300)
Catalog No.: PC-20750Not For Human Use, Lab Use Only.
TOP5300 (TOP05300) is a potent, selective, orally active allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 9.72 nM, 80-fold selectivity over hLHR.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TOP5300 (TOP05300) is a potent, selective, orally active allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 9.72 nM, 80-fold selectivity over hLHR.
TOP5300 stimulated concentration-dependent increases in estradiol production in the absence or presence of a low concentration of rec-hFSH (0.2 pM) in cultured rat granulosa cells.
TOP5300 also stimulated concentration-dependent increases in testosterone production from cultured rat Leydig cells.
TOP5300 is a full agonist on the FSH receptor in human granulosa cells, stimulates estradiol production with EC50 of 474 nM.
TOP5300 (5, 10 and 25 mg/kg, p.o.) stimulated follicular maturation in immature rats.
Physicochemical Properties
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M.Wt
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570.47
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Formula
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C28H29Cl2N5O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C1=NN(C2=CC(Cl)=CC(Cl)=C2)C3=C1COC4=C3C=C(C5=CN(CCO)N=C5)C(OC)=C4)N(C(C)(C)C)C
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References
1. Selva Nataraja, et al. Front Pharmacol. 2021 Jan 14;11:602593.
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