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TP-020

Chemical Structure : TP-020

CAS No.: 1800025-30-2

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TP-020 (TP020)

Catalog No.: PC-21222Not For Human Use, Lab Use Only.

TP-020 is a potent, selective, orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TP-020 is a potent, selective, orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.
TP-020 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice.
TP-020 (30 mg/kg) significantly reduces food intake dose dependently, suppresses body weight gains, shows anti-diabetic effects in mice.

Physicochemical Properties

M.Wt 654.01
Formula C27H21ClF5N7O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Chloro-2,6-difluorophenyl)-2,3-dihydro-1-[5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-pyrimidinyl]-7-(2-oxo-1-pyrrolidinyl)-1H-indole-5-sulfonamide

References

1. Take K, et al. PLoS One. 2016 Mar 3;11(3):e0150976.

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