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TP-3654

Chemical Structure : TP-3654

CAS No.: 1361951-15-6

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TP-3654 (TP3654;TP 3654)

Catalog No.: PC-42322Not For Human Use, Lab Use Only.

TP-3654 is a potent, selective, orally active second-generation PIM inhibitor with Ki of 5, 42 and 239 nM for Pim1, 2 and 3, respectively.

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10 mg $118 In stock
25 mg $188 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TP-3654 is a potent, selective, orally active second-generation PIM inhibitor with Ki of 5, 42 and 239 nM for Pim1, 2 and 3, respectively.
TP-3654 exhibits submicromolar activity in UM-UC-3 bladder cancer cell line.
TP-3654 displays favorabl hERG and CYP450 inhibition profiles compared with SGI-1776, reduces tumor growth in vivo xenografts.

Physicochemical Properties

M.Wt 418.4553096
Formula C22H25F3N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 10 mM
Chemical Name/SMILES

Cyclohexanemethanol, α,α-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans-

References

1. Foulks JM, et al. Neoplasia. 2014 May;16(5):403-12.

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