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Chemical Structure : TPEN
CAS No.: 16858-02-9
Catalog No.: PC-42082Not For Human Use, Lab Use Only.
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $78 | In stock | |
| 250 mg | $118 | In stock | |
| 500 mg | $188 | In stock | |
| 1 g | Get quote |
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TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator.
TPEN (TPEDA) completely inhibits LIN28-mediated oligouridylation at 40 uM.
TPEN (TPEDA) targets only the C-terminal zinc-knuckle domain (ZKD) domain of LIN28 and causes drastic structural changes of the zinc knuckles and RNA-binding residues in the ZKD.
TPEN (TPEDA) was previously shown to induce apoptosis by chelating Zn2+ in cells.
| M.Wt | 424.5407 | |
| Formula | C26H28N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)- |
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1. Shumaker DK, et al. Cell Calcium. 1998 Feb-Mar;23(2-3):151-64.
2. Ahn YH, et al. Exp Neurol. 1998 Nov;154(1):47-56.
3. Makhov P, et al. Cell Death Differ. 2008 Nov;15(11):1745-51.
4. Wang L, et al. Cell Rep. 2018 Jun 5;23(10):3091-3101.
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