Chemical Structure : TPP-IOA
CAS No.:
1423018-61-4
TPP-IOA
Catalog No.: PC-21418Not For Human Use, Lab Use Only.
TPP-IOA is a specific inhibitor of cytochrome c (cyt c) peroxidase activity, inhibits peroxidase activity of cardiolipin-induced cytochrome c peroxidase activity with IC50 of 5 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TPP-IOA is a specific inhibitor of cytochrome c (cyt c) peroxidase activity, inhibits peroxidase activity of cardiolipin-induced cytochrome c peroxidase activity with IC50 of 5 uM.
TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol.
TPP-IOA dose-dependently inhibits the rate of resorufin formation of the cytochrome c/cardiolipin solution.
TPP-IOA is a specific mitochondria-targeted anti-peroxidase agent inhibiting mono-lyso-CL (MLCL)-cyt c peroxidase activity.
TPP-IOA (5 uM) significantly suppresses resorufin formation in isolated mitochondria.
TPP-IOA prevents phospholipid peroxidation, improves mitochondrial respiration of TAZ-deficient C2C12 myoblasts and restores exercise endurance in a Barth syndrome (BTHS) Drosophila model.
Physicochemical Properties
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M.Wt
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731.80
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Formula
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C42H56BrN2O2P
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(Z)-(3-((12-(1H-imidazol-1-yl)octadec-9-enoyl)oxy)propyl)triphenylphosphonium bromide
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References
1. Lucas A Maddalena, et al. Biochim Biophys Acta Bioenerg. 2017 Jan;1858(1):73-85.
2. Kagan VE, et al. Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome. Nat Metab. 2023 Nov 23. doi: 10.1038/s42255-023-00926-4.
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