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TPPB

Chemical Structure : TPPB

CAS No.: 497259-23-1

TPPB (PKC activator TPPB)

Catalog No.: PC-38022Not For Human Use, Lab Use Only.

TPPB is a highly potent, selectiveand cell permeable protein kinase C (PKC) activator with Ki of 11.9 nM.

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Biological Activity

TPPB is a highly potent, selectiveand cell permeable protein kinase C (PKC) activator with Ki of 11.9 nM.
TPPB induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells.
TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.

Physicochemical Properties

M.Wt 501.54
Formula C27H30F3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2E,4E)-N-((2S,5S)-5-(hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydrobenzo[e][1,4]diazocin-8-yl)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide

References

1. Alan P Kozikowski, et al. J Med Chem. 2003 Jan 30;46(3):364-73.

2. Yang HQ, et al. Eur J Neurosci. 2007 Jul;26(2):381-91.

3. Yi P, et al. J Mol Neurosci. 2012 Sep;48(1):234-44.

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