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TPPU

Chemical Structure : TPPU

CAS No.: 1222780-33-7

TPPU (sHE inhibitor TPPU)

Catalog No.: PC-42350Not For Human Use, Lab Use Only.

TPPU is a potent soluble epoxide hydrolase (sHE) inhibitor with IC50 of 37 nM and 3.7 nM for monkey and human sHE, respectively.

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Biological Activity

TPPU is a potent soluble epoxide hydrolase (sHE) inhibitor with IC50 of 37 nM and 3.7 nM for monkey and human sHE, respectively.
TPPU attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice.
TPPU significantly decreases not only the percentages but also the proliferative capacity of different populations of cardiac fibroblasts.
TPPU also reduces the migration of fibroblasts into the heart from the bone marrow in vivo.

Physicochemical Properties

M.Wt 359.3435096
Formula C16H20F3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

Urea, N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-

References

1. Sirish P, et al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5618-23.

2. Ulu A, et al. Br J Pharmacol. 2012 Mar;165(5):1401-12.

3. Ren Q, et al. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1944-52.

4. Goswami SK, et al. oxicol Appl Pharmacol. 2015 Dec 15;289(3):419-27.

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