Chemical Structure : TQ416
CAS No.:
950388-70-2
TQ416
(TQ-416)
Catalog No.: PC-26444Not For Human Use, Lab Use Only.
TQ416 is a small molecule paraoxonase 2 (PON2) inhibitor, restores NF-κB transcriptional activity suppressed by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12HSL, C12) with IC50 of 400 nM, rescues 3OC12HSL-induced cell death.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TQ416 is a small molecule paraoxonase 2 (PON2) inhibitor, restores NF-κB transcriptional activity suppressed by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12HSL, C12) with IC50 of 400 nM, rescues 3OC12HSL-induced cell death.
TQ416 inhibits 3OC12HSL hydrolysis and to prevent cytosolic acidification in HEK293T cells.
TQ416 (0.5-5 uM) rescues 3OC12HSL-induced cell death through PON2 inhibition.
Treatment with C12-HSL at 100 μM for 4 h markedly decreased MUC2 production in LS174T cells and TQ416 (1 μM) completely restored this decrease.
TQ416 significantly attenuated the production of IL-8 and IL-1β compared with the C12-HSL alone in LS174T cells.
TQ416 fully restored NF-κB transcriptional responses in LPS-stimulated FRT-NF-κB cells with IC50 of 400 nM.
TQ416 inhibits N-(3-oxo-dodecanoyl) homoserine lactone (C12) action to restore cytokine secretion in LPS-stimulated cells.
Physicochemical Properties
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M.Wt
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363.48
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Formula
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C21H21N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5,9-dimethyl-1-((2-(p-tolyloxy)ethyl)thio)-[1,2,4]triazolo[4,3-a]quinoline
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References
1. Tao S, et al. Sci Rep. 2016 Jul 1;6:28778.
2. Tao S, et al. Life Sci. 2018 May 15;201:81-88.
3. Cathleen D Valentine, et al. Cell Microbiol. 2014 Jan;16(1):1-14.
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