Catalog No.: PC-26444Not For Human Use, Lab Use Only.
TQ416 is a small molecule paraoxonase 2 (PON2) inhibitor, restores NF-κB transcriptional activity suppressed by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12HSL, C12) with IC50 of 400 nM, rescues 3OC12HSL-induced cell death.
TQ416 is a small molecule paraoxonase 2 (PON2) inhibitor, restores NF-κB transcriptional activity suppressed by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12HSL, C12) with IC50 of 400 nM, rescues 3OC12HSL-induced cell death.
TQ416 inhibits 3OC12HSL hydrolysis and to prevent cytosolic acidification in HEK293T cells.
TQ416 (0.5-5 uM) rescues 3OC12HSL-induced cell death through PON2 inhibition.
Treatment with C12-HSL at 100 μM for 4 h markedly decreased MUC2 production in LS174T cells and TQ416 (1 μM) completely restored this decrease.
TQ416 significantly attenuated the production of IL-8 and IL-1β compared with the C12-HSL alone in LS174T cells.
TQ416 fully restored NF-κB transcriptional responses in LPS-stimulated FRT-NF-κB cells with IC50 of 400 nM.
TQ416 inhibits N-(3-oxo-dodecanoyl) homoserine lactone (C12) action to restore cytokine secretion in LPS-stimulated cells.
