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Chemical Structure : TRAF-STOP 6860766
Catalog No.: PC-62585Not For Human Use, Lab Use Only.
TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.
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TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity; prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces the CD40-induced phosphorylation of Tak1 and NF-κB p65 in BMDMs.
| M.Wt | 336.613 | |
| Formula | C15H11BrClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Seijkens TTP, et al. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.
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