Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TRAF-STOP 6860766
Catalog No.: PC-62585Not For Human Use, Lab Use Only.
TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity; prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces the CD40-induced phosphorylation of Tak1 and NF-κB p65 in BMDMs.
| M.Wt | 336.613 | |
| Formula | C15H11BrClNO | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Seijkens TTP, et al. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
