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TRAF-STOP 6860766

Chemical Structure : TRAF-STOP 6860766

CAS No.: 433234-16-3

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TRAF-STOP 6860766 (SMI-6860766;SMI6860766)

Catalog No.: PC-62585Not For Human Use, Lab Use Only.

TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity; prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces the CD40-induced phosphorylation of Tak1 and NF-κB p65 in BMDMs.

Physicochemical Properties

M.Wt 336.613
Formula C15H11BrClNO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[(4-Bromo-2-chlorophenyl)amino]-1-phenyl-2-propen-1-one

References

1. Seijkens TTP, et al. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.

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