Catalog No.: PC-70335Not For Human Use, Lab Use Only.
TRAF-STOP 6877002 (SMI-6877002) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.
TRAF-STOP 6877002 (SMI-6877002) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.
TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation.
TRAF-STOP 6877002 reduces macrophage proliferation in atherosclerotic plaques and reduces the expression of Ki67 in BMDMs.
SMI-6877002 inhibits CD40-TRAF6-dependent inflammation and ameliorates retinal vascular leakage and capillary degeneration in diabetic mice.
