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Chemical Structure : TRC102
CAS No.: 593-56-6
Catalog No.: PC-72643Not For Human Use, Lab Use Only.
TRC102 (Methoxyamine HCl, TRC-102) is a small-molecule base-excision repair (BER) inhibitor, potentiates the cytotoxicity of pemetrexed and reverses resistance by binding to chemotherapy-induced abasic sites in DNA.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $128 | In stock | |
| 500 mg | $218 | In stock | |
| 1 g | Get quote |
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TRC102 (Methoxyamine HCl, TRC-102) is a small-molecule base-excision repair (BER) inhibitor, potentiates the cytotoxicity of pemetrexed and reverses resistance by binding to chemotherapy-induced abasic sites in DNA.
Methoxyamine HCl is highly water soluble potentiates the cytotoxicity of alkylator and antimetabolite chemotherapy and reverses chemotherapy resistance by rapidly and covalently binding to chemotherapy-induced apurinic/apyrimidinic (AP, abasic) sites in DNA.
TRC102 extended median tumor growth delay in mice with human NSCLC xenografts.
| M.Wt | 83.51 | |
| Formula | CH6ClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
methoxyamine hydrochloride |
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1. Michael S Gordon, et al. Invest New Drugs. 2013 Jun;31(3):714-23.
2. Tithi Biswas, et al. Clin Cancer Res. 2022 Feb 15;28(4):646-652.
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