Catalog No.: PC-72643Not For Human Use, Lab Use Only.
TRC102 (Methoxyamine HCl, TRC-102) is a small-molecule base-excision repair (BER) inhibitor, potentiates the cytotoxicity of pemetrexed and reverses resistance by binding to chemotherapy-induced abasic sites in DNA.
TRC102 (Methoxyamine HCl, TRC-102) is a small-molecule base-excision repair (BER) inhibitor, potentiates the cytotoxicity of pemetrexed and reverses resistance by binding to chemotherapy-induced abasic sites in DNA.
Methoxyamine HCl is highly water soluble potentiates the cytotoxicity of alkylator and antimetabolite chemotherapy and reverses chemotherapy resistance by rapidly and covalently binding to chemotherapy-induced apurinic/apyrimidinic (AP, abasic) sites in DNA.
TRC102 extended median tumor growth delay in mice with human NSCLC xenografts.
Physicochemical Properties
M.Wt
83.51
Formula
CH6ClNO
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
methoxyamine hydrochloride
References
1. Michael S Gordon, et al. Invest New Drugs. 2013 Jun;31(3):714-23.
2. Tithi Biswas, et al. Clin Cancer Res. 2022 Feb 15;28(4):646-652.
