Chemical Structure : TREM2 agonist As48
CAS No.:
1214405-38-5
TREM2 agonist As48
Catalog No.: PC-25436Not For Human Use, Lab Use Only.
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis.
As48 binds to TREM2 with a KD of 13.8 uM in MST assays.
As48 binds to TREM1 with a KD of 97.92 uM, 7-fold weaker binding compared to its affinity for TREM2.
As48 demonstrates no significant cytotoxicity in HMC3 human microglial cells up to 100 uM.
As48 functions as a TREM2 agonist by inducing SYK phosphorylation and downstream calcium signaling in HEK293-hTREM2/DAP12 cells.
As48 (30 uM) activates TREM2 signaling in human microglial cells, enhances microglial phagocytic function.
As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activity, does not function as a direct ADAM protease inhibitor.
Physicochemical Properties
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M.Wt
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345.42
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Formula
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C20H15N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(5-(imidazo[1,2-a]pyridin-2-yl)indolin-1-yl)(thiophen-2-yl)methanone
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References
1. Sungwoo Cho, et al. bioRxiv [Preprint]. 2025 Aug 28:2025.08.23.671919.
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