Catalog No.: PC-25436Not For Human Use, Lab Use Only.
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis.
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis.
As48 binds to TREM2 with a KD of 13.8 uM in MST assays.
As48 binds to TREM1 with a KD of 97.92 uM, 7-fold weaker binding compared to its affinity for TREM2.
As48 demonstrates no significant cytotoxicity in HMC3 human microglial cells up to 100 uM.
As48 functions as a TREM2 agonist by inducing SYK phosphorylation and downstream calcium signaling in HEK293-hTREM2/DAP12 cells.
As48 (30 uM) activates TREM2 signaling in human microglial cells, enhances microglial phagocytic function.
As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activity, does not function as a direct ADAM protease inhibitor.
