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TRIF agonist AV-C

Chemical Structure : TRIF agonist AV-C

CAS No.: 620589-62-0

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TRIF agonist AV-C

Catalog No.: PC-63179Not For Human Use, Lab Use Only.

TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM).
    TRIF agonist AV-C activates IFNAR-mediated transcription and translation of antiviral effector genes, AV-C-mediated, IRF3-dependent innate activation occurs independently of adaptor proteins IPS-1/MAVS and STING but requires TRIF.

    Physicochemical Properties

    M.Wt 421.446
    Formula C22H16FN3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(2-fluorophenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione

    References

    1. Pryke KM, et al. MBio. 2017 May 2;8(3). pii: e00452-17.

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