Chemical Structure : TRPA1 agonist NMTA
Catalog No.: PC-25470Not For Human Use, Lab Use Only.
TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects.
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TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects.
NMTA does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6 and hTRPM8 channels individually expressed in HEK-293T cells. NMTA (10-3000 μM) could activate mTRPA1 channels in a concentration-dependent manner (EC50=314.04 uM), activated and desensitized mTRPA1 channels.
NMTA (10, 20, and 40 mg/kg, oral) demonstrates antinociceptive effects on CFA-induced inflammatory pain in mice.
M.Wt | 262.37 | |
Formula | C14H18N2OS | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Sun C, et al. ACS Chem Neurosci. 2025 Sep 3;16(17):3257-3266.
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