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TRPA1 agonist NMTA

Chemical Structure : TRPA1 agonist NMTA

CAS No.: 3083086-77-2

TRPA1 agonist NMTA

Catalog No.: PC-25470Not For Human Use, Lab Use Only.

TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects.
NMTA does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6 and hTRPM8 channels individually expressed in HEK-293T cells. NMTA (10-3000 μM) could activate mTRPA1 channels in a concentration-dependent manner (EC50=314.04 uM), activated and desensitized mTRPA1 channels.
NMTA (10, 20, and 40 mg/kg, oral) demonstrates antinociceptive effects on CFA-induced inflammatory pain in mice.

Physicochemical Properties

M.Wt 262.37
Formula C14H18N2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-methoxypropyl)-4-(p-tolyl)thiazol-2-amine

References

1. Sun C, et al. ACS Chem Neurosci. 2025 Sep 3;16(17):3257-3266.

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