TRPM2 inhibitor D10

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Chemical Structure : TRPM2 inhibitor D10

Catalog No.: PC-25551Not For Human Use, Lab Use Only.

TRPM2 inhibitor D10 is a highly seletive small molecule TRPM2 inhibitor with IC50 of 2.29 uM, demonstrates significant neuroprotective effects in vitro, shows robust efficacy in reducing cerebral infarction in a transient middle cerebral artery occlusion (tMCAO) model.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	320.39
Formula	C20H20N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Benzoyl-N,N-diethyl-7-indolizinecarboxamide

References

1. Lu T, et al. J Med Chem. 2025 Apr 10;68(7):7642-7661.

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