TRPM8 antagonist 14 |CAS:259674-19-6 Probechem Biochemicals

Chemical Structure : TRPM8 antagonist 14

CAS No.: 259674-19-6

TRPM8 antagonist 14

Catalog No.: PC-35474Not For Human Use, Lab Use Only.

TRPM8 antagonist 14 is a potent, selective TRPM8 antagonist with IC50 of 0.2 nM in calcium influx assays, shows no activity on TRPV1.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$228	In stock
50 mg	$388	In stock
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Biological Activity

TRPM8 antagonist 14 is a potent, selective TRPM8 antagonist with IC50 of 0.2 nM in calcium influx assays, shows no activity on TRPV1.
TRPM8 antagonist 14 shows significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models.

Physicochemical Properties

M.Wt	398.506
Formula	C26H26N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-methyl 2-(dibenzylamino)-3-(1H-indol-3-yl)propanoate

References

1. Bertamino A, et al. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00545.

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