TRPM8 antagonist 23

Chemical Structure : TRPM8 antagonist 23

Catalog No.: PC-24333Not For Human Use, Lab Use Only.

TRPM8 antagonist 23 is a potent and selective TRPM8 antagonist with IC50 of 0.2 uM, 10-fold higher potency for human TRPM8 (hTRPM8) than for hTRPV1 and hTRPA1 channels.

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Biological Activity

TRPM8 antagonist 23 is a potent and selective TRPM8 antagonist with IC50 of 0.2 uM, 10-fold higher potency for human TRPM8 (hTRPM8) than for hTRPV1 and hTRPA1 channels.

Physicochemical Properties

M.Wt	389.50
Formula	C25H27NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(adamantan-1-ylamino)-2-oxoethyl [1,1'-biphenyl]-2-carboxylate

References

1. Lamberti A, et al. FEBS J. 2025 Mar 23. doi: 10.1111/febs.70065.

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