TRPV1 agonist MSP20

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Chemical Structure : TRPV1 agonist MSP20

Catalog No.: PC-27337Not For Human Use, Lab Use Only.

MSP20 is a potent, selective TRPV1 agonist with EC50 of 46 nM and Emax=78.24%, shows no agonist activity against TRPV3, TRPV4 and TRPM8 receptors.

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Biological Activity

MSP20 is a potent, selective TRPV1 agonist with EC50 of 46 nM and Emax=78.24%, shows no agonist activity against TRPV3, TRPV4 and TRPM8 receptors.
MSP20 binds to the vanilloid site and a desensitized conformation of hTRPV1.
MSP20 induces reduction in ROS production in HaCaT and HUVEC cells exposed to glucose oxidase (GO).
MSP20-mediated neuroprotection seems to be strictly dependent on the canonical TRPV1 ion channel activation.
MSP20 exhibits robust and long-lasting antinociceptive activity with ex-vivo neuroprotective effects.

Physicochemical Properties

M.Wt	341.43
Formula	C19H19NO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(benzo[b]thiophen-2-yl)-N-(4-hydroxy-3-methoxybenzyl)propanamide

References

1. Neuberger A, et al. Nat Commun. 2026 Jul 6. doi: 10.1038/s41467-026-74972-3.

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