TRPV1 antagonist CX-3

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Chemical Structure : TRPV1 antagonist CX-3

Catalog No.: PC-22421Not For Human Use, Lab Use Only.

TRPV1 antagonist CX-3 is a first-in-class highly selective TRPV1 antagonist with IC50 of 26.2 nM, inhibits TRPV1 current with IC50 value of 9.71 uM in whole-cell patch-clamp assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TRPV1 antagonist CX-3 is a first-in-class highly selective TRPV1 antagonist with IC50 of 26.2 nM, inhibits TRPV1 current with IC50 value of 9.71 uM in whole-cell patch-clamp assay.
TRPV1 antagonist CX-3 displays no activity against other TRP channels (TRPV3, TRPV4 and TRPA1) (IC50>100 uM).
TRPV1 antagonist CX-3 exerts better analgesic activity in vivo than that of BCTC in the formalin induced inflammatory pain model without hyperthermia risk.
TRPV1 antagonist CX-3 exhibited robust glucose-lowering effects.

Physicochemical Properties

M.Wt	400.47
Formula	C26H24O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-methoxyphenyl)-7-((2,4,6-trimethylbenzyl)oxy)-4H-chromen-4-one

References

1. Chunxia Liu, et al. Bioorg Med Chem. 2024 May 17:107:117750.

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