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Chemical Structure : TRPV1 antagonist CX-3
Catalog No.: PC-22421Not For Human Use, Lab Use Only.
TRPV1 antagonist CX-3 is a first-in-class highly selective TRPV1 antagonist with IC50 of 26.2 nM, inhibits TRPV1 current with IC50 value of 9.71 uM in whole-cell patch-clamp assay.
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TRPV1 antagonist CX-3 is a first-in-class highly selective TRPV1 antagonist with IC50 of 26.2 nM, inhibits TRPV1 current with IC50 value of 9.71 uM in whole-cell patch-clamp assay.
TRPV1 antagonist CX-3 displays no activity against other TRP channels (TRPV3, TRPV4 and TRPA1) (IC50>100 uM).
TRPV1 antagonist CX-3 exerts better analgesic activity in vivo than that of BCTC in the formalin induced inflammatory pain model without hyperthermia risk.
TRPV1 antagonist CX-3 exhibited robust glucose-lowering effects.
| M.Wt | 400.47 | |
| Formula | C26H24O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chunxia Liu, et al. Bioorg Med Chem. 2024 May 17:107:117750.
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