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Chemical Structure : TRPV2 inhibitor IV2-1
Catalog No.: PC-20875Not For Human Use, Lab Use Only.
TRPV2 inhibitor IV2-1 is a novel TRPV2-selective blocker, inhibits 2-APB elicited typical inwardly rectifying TRPV2 currents with IC50 of 0.8 uM.
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TRPV2 inhibitor IV2-1 is a novel TRPV2-selective blocker, inhibits 2-APB elicited typical inwardly rectifying TRPV2 currents with IC50 of 0.8 uM.
TRPV2 inhibitor IV2-1 blocks TRPV2-mediated increases in [Ca2+]i in calibrated microfluorometric single-cell analysis with IC50 of 6.3 uM.
TRPV2 inhibitor IV2-1 shows no activity against rat TRPV1, mouse TRPV3, or mouse TRPV4 channels stably expressed in HEK293 cells.
Acute modulation of TRPV2 by IV2-1 inhibits macrophage migration and phagocytosis.
TRPV2 inhibition causes significant inhibitory effects on lipopolysaccharide-induced migration of macrophages whereas TRPV2 activation promotes migration.
| M.Wt | 242.36 | |
| Formula | C17H22O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rick Raudszus, et al. Br J Pharmacol. 2023 May 31. doi: 10.1111/bph.16154.
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