Chemical Structure : TRPV2 inhibitor IV2-1
CAS No.:
TRPV2 inhibitor IV2-1
Catalog No.: PC-20875Not For Human Use, Lab Use Only.
TRPV2 inhibitor IV2-1 is a novel TRPV2-selective blocker, inhibits 2-APB elicited typical inwardly rectifying TRPV2 currents with IC50 of 0.8 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TRPV2 inhibitor IV2-1 is a novel TRPV2-selective blocker, inhibits 2-APB elicited typical inwardly rectifying TRPV2 currents with IC50 of 0.8 uM.
TRPV2 inhibitor IV2-1 blocks TRPV2-mediated increases in [Ca2+]i in calibrated microfluorometric single-cell analysis with IC50 of 6.3 uM.
TRPV2 inhibitor IV2-1 shows no activity against rat TRPV1, mouse TRPV3, or mouse TRPV4 channels stably expressed in HEK293 cells.
Acute modulation of TRPV2 by IV2-1 inhibits macrophage migration and phagocytosis.
TRPV2 inhibition causes significant inhibitory effects on lipopolysaccharide-induced migration of macrophages whereas TRPV2 activation promotes migration.
Physicochemical Properties
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M.Wt
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242.36
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Formula
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C17H22O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-cyclopentylidene-4-methyl-5-phenylpentan-2-one
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References
1. Rick Raudszus, et al. Br J Pharmacol. 2023 May 31. doi: 10.1111/bph.16154.
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