TRPV6 inhibitor cis-22a TFA

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Chemical Structure : TRPV6 inhibitor cis-22a TFA

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Catalog No.: PC-25399Not For Human Use, Lab Use Only.

TRPV6 inhibitor cis-22a TFA is a potent, selective inhibitor of TRPV6 calcium channel with IC50 of 0.32 uM, shows high selectivity against other calcium channels and related TRP targets, selectively reduces cancer cell growth on TRPV6 positive (T47D) breast cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	563.54
Formula	C26H31F6N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Piperazine, 1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(3-pyridinyl)-, 2,2,2-trifluoroacetate (1:2)

References

1. Simonin C, et al. Angew. Chem. Int. Ed. Engl. 54, 14748–14752 (2015).

2. Bhardwaj R, et al. Sci Adv. 2020 Nov 27;6(48):eabe1508.

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