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Chemical Structure : TSLP inhibitor BP79
Catalog No.: PC-22534Not For Human Use, Lab Use Only.
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.
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TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.
BP79 effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.
BP79 inhibits TSLP-induced IL-4/IL-13 expression in primary CD4 + T cells with inhibitory effects (≥80% inhibition) at 10 µM and 20 µM concentrations.
BP79 abolishes TSLPR complex formation without broad-spectrum kinase inhibitory effects.
BP79 efficiently penetrates human skin and inhibits TSLP-mediated inflammation in an atopic-like skin disease model.
BP79 exerts potent anti-inflammatory effects in an atopic diseases-organ chip.
| M.Wt | 259.09 | |
| Formula | C10H8Cl2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Adhikary PP, et al. EMBO Mol Med. 2024 Jun 14. doi: 10.1038/s44321-024-00085-3.
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