You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-TSLP inhibitor BP79
TSLP inhibitor BP79

Chemical Structure : TSLP inhibitor BP79

CAS No.:

TSLP inhibitor BP79 (TSLP-TSLP receptor inhibitor)

Catalog No.: PC-22534Not For Human Use, Lab Use Only.

TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.

Packing Price Stock Quantity
5 mg $358 In stock
10 mg $548 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.
BP79 effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.
BP79 inhibits TSLP-induced IL-4/IL-13 expression in primary CD4 + T cells with inhibitory effects (≥80% inhibition) at 10 µM and 20 µM concentrations.
BP79 abolishes TSLPR complex formation without broad-spectrum kinase inhibitory effects.
BP79 efficiently penetrates human skin and inhibits TSLP-mediated inflammation in an atopic-like skin disease model.
BP79 exerts potent anti-inflammatory effects in an atopic diseases-organ chip.

Physicochemical Properties

M.Wt 259.09
Formula C10H8Cl2N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N1-(3,4-dichlorophenyl)maleamide

References

1. Adhikary PP, et al. EMBO Mol Med. 2024 Jun 14. doi: 10.1038/s44321-024-00085-3.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: