Catalog No.: PC-22534Not For Human Use, Lab Use Only.
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.
BP79 effectively abrogates TSLP-triggered cytokines at low micromolar concentrations.
BP79 inhibits TSLP-induced IL-4/IL-13 expression in primary CD4 + T cells with inhibitory effects (≥80% inhibition) at 10 µM and 20 µM concentrations.
BP79 abolishes TSLPR complex formation without broad-spectrum kinase inhibitory effects.
BP79 efficiently penetrates human skin and inhibits TSLP-mediated inflammation in an atopic-like skin disease model.
BP79 exerts potent anti-inflammatory effects in an atopic diseases-organ chip.
Physicochemical Properties
M.Wt
259.09
Formula
C10H8Cl2N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N1-(3,4-dichlorophenyl)maleamide
References
1. Adhikary PP, et al. EMBO Mol Med. 2024 Jun 14. doi: 10.1038/s44321-024-00085-3.
