TTBK1 inhibitor 31

Chemical Structure : TTBK1 inhibitor 31

Catalog No.: PC-22792Not For Human Use, Lab Use Only.

TTBK1 inhibitor 31 is a potent, selective and CNS-penetrant Tau Tubulin Kinase 1 (TTBK1) inhibitor with IC50 of 2.7 nM, inhibits tau phosphorylation at the disease-relevant Ser 422 epitope.

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Biological Activity

TTBK1 inhibitor 31 is a potent, selective and CNS-penetrant Tau Tubulin Kinase 1 (TTBK1) inhibitor with IC50 of 2.7 nM, inhibits tau phosphorylation at the disease-relevant Ser 422 epitope.

Physicochemical Properties

M.Wt	337.38
Formula	C18H19N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3S)-

References

1. Halkina T, et al. J Med Chem. 2021 May 13;64(9):6358-6380.

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