TTFB | ZAC antagonist | Probechem Biochemicals

Chemical Structure : TTFB

CAS No.: 352560-76-0

TTFB (ZAC antagonist TTFB)

Catalog No.: PC-72756Not For Human Use, Lab Use Only.

TTFB (ZAC antagonist TTFB) is a selective antagonist (negative allosteric modulator) of Zinc-Activated Channel (ZAC) with IC50 of 3 uM.

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Biological Activity

TTFB (ZAC antagonist TTFB) is a selective antagonist (negative allosteric modulator) of Zinc-Activated Channel (ZAC) with IC50 of 3 uM.
TTFB dispalys no significant agonist, antagonist or modulatory activity on a panel of four classical CLR subfamilies: the m5-HT3AR, the hα3β4 nAChR, the hα1β2γ2S GABAAR and the hα1 GlyR.
TTFB mediates equipotent and voltage-independent inhibition of agonist-evoked and spontaneous ZAC signaling.

Physicochemical Properties

M.Wt	278.345
Formula	C14H15FN2OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility
Chemical Name/SMILES

References

1. Nawid Madjroh, et al. Biochem Pharmacol. 2021 Nov;193:114782.

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TTFB (ZAC antagonist TTFB)

Biological Activity

Physicochemical Properties

References

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