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TTGM 5826

Chemical Structure : TTGM 5826

CAS No.: 330471-93-7

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TTGM 5826 (TTGM-5826;TTGM5826)

Catalog No.: PC-35734Not For Human Use, Lab Use Only.

TTGM 5826 (TTGM5826, TTGM-5826) is a small molecule, potential modulator of tissue transglutaminase (tTG) conformation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TTGM 5826 (TTGM5826, TTGM-5826) is a small molecule, potential modulator of tissue transglutaminase (tTG) conformation.
    TTGM 5826 broadly inhibits the transformed phenotypes of breast and brain cancer cell lines, as well as glioma stem cells.
    TTGM 5826 promotes the toxicity of cancer cells by stabilizing the open state of tTG.

    Physicochemical Properties

    M.Wt 480.48
    Formula C27H20N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-5-(((3-((1,3-dioxoisoindolin-2-yl)methyl)-4-methylphenyl)amino)methylene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

    References

    1. Katt WP, et al. Oncotarget. 2018 Sep 28;9(76):34379-34397.

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