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TTZ-2

Chemical Structure : TTZ-2

CAS No.: 103178-32-1

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TTZ-2 (zDHHC2 inhibitor TTZ2)

Catalog No.: PC-25635Not For Human Use, Lab Use Only.

TTZ-2 (zDHHC2 inhibitor TTZ2) is a specific enzymatic inhibitor of ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation  in vitro with IC50 of 1.3 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TTZ-2 (zDHHC2 inhibitor TTZ2) is a specific enzymatic inhibitor of ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation  in vitro with IC50 of 1.3 uM.
TTZ-2 inhibits zDHHC2-mediated SNAP25 S-acylation in cells with IC50 of 19 uM in HEK293T cells transfected with plasmids encoding GFP-tagged SNAP25b and HA-tagged zDHHC2.
TTZ-2 shows no effect on S-acylation of SNAP25 by zDHHC3 and zDHHC7.
TTZ-2 (25 uM) significantly inhibits PSD95-mCHERRY S-acylation by zDHHC2 and zDHHC15 in HEK293T cells.

Physicochemical Properties

M.Wt 470.53
Formula C26H26N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(1H-tetrazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)-4-(4-phenylbutoxy)benzamide

References

1. Salaun C, et al. J Biol Chem. 2022 Oct;298(10):102469.

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