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TWS119

Chemical Structure : TWS119

CAS No.: 601514-19-6

TWS119 (TWS 119, TWS-119)

Catalog No.: PC-42674Not For Human Use, Lab Use Only.

TWS119 is a potent GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay.

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25 mg $128 In stock
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100 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TWS119 is a potent GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay.
TWS119 can induce neurogenesis in murine ESCs; reduces Cdon levels and aberrant Cx43 activitiesin rat cardiomyocytes.
TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats.

Physicochemical Properties

M.Wt 318.3293
Formula C18H14N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Phenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-

References

1. Ding S, et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7.

2. Wang W, et al. Mol Neurobiol. 2016 Dec;53(10):7028-7036.

3. Jeong MH, et al. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1345-E1354.

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