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Tacaciclib

Chemical Structure : Tacaciclib

CAS No.: 2768774-66-7

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Tacaciclib (AUR-102, XL-102, XL102, AUR102)

Catalog No.: PC-23060Not For Human Use, Lab Use Only.

Tacaciclib (XL102, AUR102) is a potent, orally bioavailable, highly selective covalent CDK7 inhibitor.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Tacaciclib (XL102, AUR102) is a potent, orally bioavailable, highly selective covalent CDK7 inhibitor.
Tacaciclib (XL102, AUR102) selectively targets, covalently binds to and inhibits the activity of CDK7, thereby inhibiting CDK7-mediated signaling.
Tacaciclib (XL102, AUR102) prevents phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II, thereby preventing transcription of important cancer-promoting genes.

Physicochemical Properties

M.Wt 528.65
Formula C30H36N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(αS)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-α-(1-methylethyl)-3-[6-[[(2E)-4-(4-morpholinyl)-1-oxo-2-buten-1-yl]amino]-3-pyridinyl]benzeneacetamide

References

1. Amita Patnaik, et al. Cancer Res (2023) 83 (5_Supplement): P4-01-35.

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